Diplomas/DegreesPh. D., Rensselaer Polytechnic Institute (2007)
B.S., Rensselaer Polytechnic Institute (2003)
Recent CoursesOrganic Chemistry I
Organic Chemistry I Lab
Organic Chemistry I I
Organic Chemistry II Lab
Research Seminars In Chemistry
Research Seminars In Chemistry I
Research Seminars In Chemistry I I
Research Seminars In Chemistry
Undergraduate Research In Chemistry I
Undergraduate Research In Chemistry II
Teaching Specializations/InterestsOrganic, Medicinal and Biochemistry
Research InterestsFluorometric high-throughput screening (HTS) assays for cytochrome P450s (CYPs)
Grants/Sponsored ResearchAdelphi Faculty Development Grant 2011
Refereed ArticlesWentland, Mark P.; Jo, Sunjin; Gargano, Joseph M.; VanAlstine, Melissa A.; Cohen, Dana J.; Bidlack, Jean M. (2012), Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: Oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC. Bioorganic & Medicinal Chemistry Letters, in Press (Ahead of Print).
Yang, J., VanAlstine, M.A., Phillips, J. G., Wntland, M. P., Hough, L.B. (2012), Cytochrome P450 2C24: expression, tissue distribution, high-throughput assay, and pharmacological inhibition. Acta Pharmaceutica Sinica B, 2, 137-145.
VanAlstine, M.A., Hough, L.B. (2011), Effects of acetylenic epoxygenase inhibitors on recombinant cytochrome P450s. Drug Metabolism and Disposition, 39, 1221-1226.
Hough L.B., Nalwalk J.W., Yang J., Conroy J.L., VanAlstine M.A., Yang W, et al. (2011), Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic. Pain, 152, 878-887.
Conroy, J. L., Fang, C., Gu, J., Zeitlin, S. O., Yang, W., Yang, J., VanAlstine, M. A., Nalwalk, J. W., Albrecht, P. J., Mazurkiewicz, J. E., Snyder-Keller, A., Shan, Z., Zhang, S., Wentland, M. P., Behr, M., Knapp, B. I., Bidlack, J. M., Zuiderveld, O. P (2010), Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling. Nature Neuroscience, 13, 284-28.
Wentland, M.P., Lou, R., Lu, Q., Bu, Y., Denhardt, C., Jin, J., Ganorkar, R., VanAlstine, M.A., Guo, C., Cohen, D.J., Bidlack, J.M. (2009), Syntheses of novel high affinity ligands for opioid receptors. BMCL, 19, 2289--2294.
Wentland, M. P., Lou, R., Lu, Q., Bu, Y., VanAlstine, M.A., Cohen, D. J., Bidlack, J.M. (2009), Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. BMCL, 19, 203-208.
VanAlstine, M. A.; Wentland, M. P.; Cohen, D. J.; Bidlack, J. M. (2007), Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4-phenyl)-phenethyl) analogues of 8-CAC. BMCL, 17, 6516-6520.
Wentland, M. P.; VanAlstine, M. A.; Kucejko, R.; Lou, R.; Cohen, D. J.; Parkhill, A. L.; Bidlack, J. M. (2006), Redefining the Structure-Activity Relationships of 2,6-Methano-3-benzazocines. 4. Opioid Receptor Binding Properties of 8-[N-(4'-phenyl)-phenethyl) carboxamido] Analogues of Cyclazocine and Ethylketocycalzocine. J. Med. Chem, 49, 5635-5639.
Lou, R.; VanAlstine, M.; Sun, X.; Wentland, M. P. (2003), Preparation of N-hydroxy succinimido esters via palladium-catalyzed carbonylation of aryl triflates and halides. Tetrahedron Letters, 44, 2477-2480.
Invited Presentation/LectureVanAlstine, M. A. (2010, September). Design of Fluorometric High-Throughput Screening Assays for Cytochrome P450 assays. Long Island Subsection of the NY-ACS.
VanAlstine, M. A. (2010, April). Design, Synthesis and Evaluation of Novel N-Substituted Derivatives of 8-Carboxamidocyclazocine. Hofstra University Chemistry Club.
VanAlstine, M. A. (2010, March). Design of Novel Fluorometric High-Throughput Screening Assays for Cytochrome P450s with Highly Selective Substrates and Inhibitors. St. Johns University Chemistry Club.
VanAlstine, M. A (2010, January). Optimization of Fluorometric High-Throughput Screening Assays for Cytochrome P450s. Brookhaven National Labs.
VanAlstine, M. A. (2009, November). Pain Killers. Adelphi University Chemistry Club.
Conference Presentations/PapersVanAlstine, Melissa A.; Fowler, Joanna; Raymond, Lendelle; Rayani, Nikita; Polson, Grace; Sikorski, Kylie; Lian, Ailin (2012). Screening vorozole on a series of human liver cytochrome P450s. In 243rd ACS National Meeting & Expositio. San Diego, CA.
VanAlstine, M. A., Jia, X., Jo, S., Gargano, J. M., Bilack, J. M., Cohen, D. J., Wentland, M. P (2011). Lead optimization studies of N-(2-[1,1-biphenyl]-4ylethyl)-8-CAC (1). In American Chemical Society 241th National Meeting. Anaheim, CA.
VanAlstine, M. A., Parkin, D.: (2010). Critical Thinking assignment: Equipping students to write and reflect. In 21st Biennial Conference on Chemical Education. University of North Texas, Denton, TX.
VanAlstine, M. A., Hough, L.B (2008). Rat CYP2B1, CYP2C6 and CYP2C11: Optimization of fluorometric high throughput screens and epoxygenase inhibitor profiles. In 236th ACS National Meeting. Philadelphia, PA.
J. L. Conroy, J.L., Nalwalk, J., VanAlstine, M.A., Knapp, B.I., Bidlack, J.M., Zuiderveld, O.P., Leurs, R., Shan, Z., Zhang, S., Wentland, M.P. and Hough, L.B., (2008). Blockade of morphine antinociception by inhibitors of cytochrome P450 and arachidonate epoxygenase. In Soc. Neurosci.. San Diego, CA.
VanAlstine, M. A., Hough, L.B. (2008). Optimization Of A Fluorometric High Throughput Screen For Rat CYP2B1 And Its Inhibition By Imidazole-Containing Compounds. In 17th International Symposium on Microsomes and Drug Oxidations. Saratoga Springs, NY.
VanAlstine, M. A.; Wentland, M. P.; Kucejko, R. J.; Lou, R.; Cohen, D.; Knapp, B. I.; Bidlack, J. M. (2006). Synthesis and Evaluation of Novel N-substituted Derivatives of 8-Carboxamidocyclazocine. In 231th ACS National Meeting. Atlanta, GA.
Wentland, M. P.; Lou, R.; VanAlstine, M. A.; Sun, X.; Lu, Q.; Bu, Y.; Bidlack, J. M. (2003). Synthesis of carboxamido-containing opiates via N-hydroxysuccinimido activated esters. In 31st Northeast Regional Meeting of the American Chemical Society. Saratoga Springs, NY.
Honors and AccomplishmentsNIH Post-doctoral Fellow, Albany Medical College 2007-2009
John and Mary Cloke Prize, Rensselaer Polytechnic Institute, 2003
The Arthur G. Schultz Award for Undergraduate Research in Organic Chemistry, 2001
Professional ActivitiesAmerican Chemical Society
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