Faculty & Staff

MELISSA A VAN ALSTINE-PARRIS

ASSISTANT PROFESSOR

CHEMISTRY

SCIENCE BUILDING
ROOM 324

p - 516-877-4133

f - 516-877-4485

e - MVANALSTINE@ADELPHI.EDU

 

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Diplomas/Degrees

PhD Organic/Medicinal Chemistry, Rensselaer Polytechnic Institute (2007)
BS Chemistry, Rensselaer Polytechnic Institute (2003)

Teaching Specializations/Interests

Organic and Medicinal Chemistry

Research Interests

Fluorometric high-throughput screening (HTS) assays for cytochrome P450s (CYPs)
Synthesis of Fluorinated compounds for 19F NMR Experiments
Synthesis of Improgan Derivatives to Improve Blood-Brain Barrier Penetration

Grants/Sponsored Research

Adelphi Faculty Development Grant, $2,000, awarded February 2013
Titled: Synthesis of Fluorinated ATP Derivatives for 19F NMR Experiments
Adelphi Faculty Development Grant, $3500, awarded February 2011
Titled: Using Fluorometric High-throughput Screening Assays to Test Vorozole on a Series of Cytochrome P450s
Adelphi University Instructional Technology Grant, $2,068 joint with B. Stockman, Molecular Visualization and Presentation Software to Improve Chemistry and Biochemistry Learning Outcomes, awarded February 2011

Refereed Articles

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VanAlstine, Melissa A.; Wentland, Mark P.; Alvarez, Juan; Cao, Qing; Cohen, Dana J.; Knapp, Brian I.; Bidlack, Jean M. (2013), Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors. Bioorganic & Medicinal Chemistry Letters, 23(7), 2128-2133.

Wentland, Mark P.; Jo, Sunjin; Gargano, Joseph M.; VanAlstine, Melissa A.; Cohen, Dana J.; Bidlack, Jean M. (2012), Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: Oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC. Bioorganic & Medicinal Chemistry Letters, 22(24), 7340-4.

Yang, J., VanAlstine, M.A., Phillips, J. G., Wntland, M. P., Hough, L.B. (2012), Cytochrome P450 2C24: expression, tissue distribution, high-throughput assay, and pharmacological inhibition. Acta Pharmaceutica Sinica B, 2, 137-145.

VanAlstine, M.A., Hough, L.B. (2011), Effects of acetylenic epoxygenase inhibitors on recombinant cytochrome P450s. Drug Metabolism and Disposition, 39, 1221-1226.

Hough L.B., Nalwalk J.W., Yang J., Conroy J.L., VanAlstine M.A., Yang W, et al. (2011), Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic. Pain, 152, 878-887.

Conroy, J. L., Fang, C., Gu, J., Zeitlin, S. O., Yang, W., Yang, J., VanAlstine, M. A., Nalwalk, J. W., Albrecht, P. J., Mazurkiewicz, J. E., Snyder-Keller, A., Shan, Z., Zhang, S., Wentland, M. P., Behr, M., Knapp, B. I., Bidlack, J. M., Zuiderveld, O. P (2010), Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling. Nature Neuroscience, 13, 284-28.

Wentland, M.P., Lou, R., Lu, Q., Bu, Y., Denhardt, C., Jin, J., Ganorkar, R., VanAlstine, M.A., Guo, C., Cohen, D.J., Bidlack, J.M. (2009), Syntheses of novel high affinity ligands for opioid receptors. BMCL, 19, 2289--2294.

Wentland, M. P., Lou, R., Lu, Q., Bu, Y., VanAlstine, M.A., Cohen, D. J., Bidlack, J.M. (2009), Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. BMCL, 19, 203-208.

VanAlstine, M. A.; Wentland, M. P.; Cohen, D. J.; Bidlack, J. M. (2007), Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4-phenyl)-phenethyl) analogues of 8-CAC. BMCL, 17, 6516-6520.

Wentland, M. P.; VanAlstine, M. A.; Kucejko, R.; Lou, R.; Cohen, D. J.; Parkhill, A. L.; Bidlack, J. M. (2006), Redefining the Structure-Activity Relationships of 2,6-Methano-3-benzazocines. 4. Opioid Receptor Binding Properties of 8-[N-(4'-phenyl)-phenethyl) carboxamido] Analogues of Cyclazocine and Ethylketocycalzocine. J. Med. Chem, 49, 5635-5639.

Lou, R.; VanAlstine, M.; Sun, X.; Wentland, M. P. (2003), Preparation of N-hydroxy succinimido esters via palladium-catalyzed carbonylation of aryl triflates and halides. Tetrahedron Letters, 44, 2477-2480.


Invited Presentation/Lecture

VanAlstine, M. A. (2010, September). Design of Fluorometric High-Throughput Screening Assays for Cytochrome P450 assays. Long Island Subsection of the NY-ACS.

VanAlstine, M. A. (2010, April). Design, Synthesis and Evaluation of Novel N-Substituted Derivatives of 8-Carboxamidocyclazocine. Hofstra University Chemistry Club.

VanAlstine, M. A. (2010, March). Design of Novel Fluorometric High-Throughput Screening Assays for Cytochrome P450s with Highly Selective Substrates and Inhibitors. St. Johns University Chemistry Club.

VanAlstine, M. A (2010, January). Optimization of Fluorometric High-Throughput Screening Assays for Cytochrome P450s. Brookhaven National Labs.

VanAlstine, M. A. (2009, November). Pain Killers. Adelphi University Chemistry Club.


Conference Presentations/Papers

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VanAlstine, Melissa A.; Fowler, Joanna; Raymond, Lendelle; Rayani, Nikita; Polson, Grace; Sikorski, Kylie; Lian, Ailin (2012). Screening vorozole on a series of human liver cytochrome P450s. In 243rd ACS National Meeting & Expositio. San Diego, CA.

VanAlstine, M. A., Jia, X., Jo, S., Gargano, J. M., Bilack, J. M., Cohen, D. J., Wentland, M. P (2011). Lead optimization studies of N-(2-[1,1-biphenyl]-4ylethyl)-8-CAC (1). In American Chemical Society 241th National Meeting. Anaheim, CA.

VanAlstine, M. A., Parkin, D.: (2010). Critical Thinking assignment: Equipping students to write and reflect. In 21st Biennial Conference on Chemical Education. University of North Texas, Denton, TX.

VanAlstine, M. A., Hough, L.B (2008). Rat CYP2B1, CYP2C6 and CYP2C11: Optimization of fluorometric high throughput screens and epoxygenase inhibitor profiles. In 236th ACS National Meeting. Philadelphia, PA.

J. L. Conroy, J.L., Nalwalk, J., VanAlstine, M.A., Knapp, B.I., Bidlack, J.M., Zuiderveld, O.P., Leurs, R., Shan, Z., Zhang, S., Wentland, M.P. and Hough, L.B., (2008). Blockade of morphine antinociception by inhibitors of cytochrome P450 and arachidonate epoxygenase. In Soc. Neurosci.. San Diego, CA.

VanAlstine, M. A., Hough, L.B. (2008). Optimization Of A Fluorometric High Throughput Screen For Rat CYP2B1 And Its Inhibition By Imidazole-Containing Compounds. In 17th International Symposium on Microsomes and Drug Oxidations. Saratoga Springs, NY.

VanAlstine, M. A.; Wentland, M. P.; Kucejko, R. J.; Lou, R.; Cohen, D.; Knapp, B. I.; Bidlack, J. M. (2006). Synthesis and Evaluation of Novel N-substituted Derivatives of 8-Carboxamidocyclazocine. In 231th ACS National Meeting. Atlanta, GA.

Wentland, M. P.; Lou, R.; VanAlstine, M. A.; Sun, X.; Lu, Q.; Bu, Y.; Bidlack, J. M. (2003). Synthesis of carboxamido-containing opiates via N-hydroxysuccinimido activated esters. In 31st Northeast Regional Meeting of the American Chemical Society. Saratoga Springs, NY.


Honors and Accomplishments

NIH Post-doctoral Fellow, Albany Medical College 2007-2009
John and Mary Cloke Prize, Rensselaer Polytechnic Institute, 2003
The Arthur G. Schultz Award for Undergraduate Research in Organic Chemistry, 2001

Professional Activities

American Chemical Society
Nassau Section of the Science Teacher Association of New York State