Faculty & Staff

BENJAMIN WEEKS

PROFESSOR

BIOLOGY

SCIENCE BUILDING
ROOM 112

p - 516-877-4193

f - 516-877-4209

e - WEEKS@adelphi.edu

w - http://home.adelphi.edu/weeks

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Recent Courses

Biology Of Aids
Developmental Biology
Developmental Biology ( Lab )
Guided Research In Biology Microbiology Laboratory
Microbiology
Microbiology ( L A B )
Microbiology ( Lab )
Microbiology ( Lecture )
Microbiology Lab
Virology

Research Interests

My research focuses on the effects of xenobiotics on the cellular mechanisms of development and disease.

Grants/Sponsored Research

2007 - 2010 Nature's Value, "Pesticide Toxicity to Soil Microorganisms, $12000.00/year for three years ($36,000.00)

2008 - 2012 Innovation Laboraotires
The effect of Pyrethroid Pesticides on Neurite Outgrowth.
$3000.00/year for four years ($12,000.00)

Books

Benjamin S. Weeks, Ph.D. and I.E. Alcamo (2007). Microbes and Society. Boston, MA: Jones and Bartlett.

Benjamin S. Weeks, Ph.D. and I.E. Alcamo, Ph.D. (2006). AIDS: The Biological Basis. Boston, MA: Jones and Bartlett.

Kleinman, H.K., M.C. Kibbey, F.B. Cannon, B.S. Weeks, and D.S. Grant. (1995). Use of extracellular matrix and its components in culture., In: Extracellular Matrix Molecules. A Practical Approach. Oxford Univ. Press.


Other Scholarly/Artistic Work

Peer-Reviewed Publications:

1. Rubenstein, E.C., T. J. Kelly, L. Clubert, CW. Woods, and B. Weeks. Ecdysteroids in developing ovarian follicles of Hyalophora cecropia. Arch. of Insect Biochem. and Physiol., 3: 253 263, 1986

2. Weeks, B.S. and N.W. Klein. In vitro and in vivo embryo toxicity of antilaminin antibodies in the rat. Am. J. Reprod. Immunol., 19: 57 64, 1989

3. Weeks, B.S., N.W. Klein, H.K. Kleinman, T. Fredrickson, and G.P. Sackett. Laminin immunized monkeys develop sera toxic to cultured rat embryos and fail to reproduce. Teratology, 40: 47 57, 1989

4. Tashiro, K., G.C. Sephel, B. Weeks, M. Sasaki, G.R. Martin, H.K. Kleinman, and Y. Yamada. A synthetic peptide containing the IKVAV sequence from the A chain of laminin mediates cell attachment, migration, and neurite outgrowth. J. Biol. Chem., 264:16174 16182, 1989

5. Kleinman, H.K. and B.S. Weeks. Laminin: structure, functions, and receptors. Current Opinion in Cell Biol., 1: 964 967, 1989

6. Weeks, B.S., Kopp, J., Horikoshi, S. Cannon, F.B. *Garrett, M. Kleinman, H.K. and P.E. Klotman. Renal cells interact with specific laminin domains via developmentally regulated binding proteins. Am. J. Physiol., 261: 688 695, 1990

7. Weeks, B.S., *Gamache, P., Klein N.W., Hinson, J.A., Bruno, M., and E. Khairallah. Acetaminophen toxicity to cultured rat embryos. TCM, 10: 361 370, 1990

8. Hadley, M.A., B.S. Weeks, H.K. Kleinman, and M.Dym. Laminin promotes tubule formation by cultured Sertoli cells. Dev. Biol., 140:318 327, 1990

9. Weeks, B., V. Papadopoulos, M. Dym, and H.K. Kleinman. cAMP promotes branching of laminin¬induced neuronal processes. J. Cellul. Physiol., 147: 62 67, 1990

10. Kleinman, H.K., M.C. Kibbey, F.B. Cannon, B.S. Weeks, and D.S. Grant. Techniques for use of extracellular matrix in culture, In Extracellular Matrix Molecules. A Practical Approach. (eds. M.A. Haralson and J.R. Hassell), Oxford Univ. Press, 1990

11. Kleinman, H.K., B.S. Weeks, F.B. Cannon, T.M. Sweeney, G.C. Sephel, B. Clement, M. Zain, O.J. Olson, M. Jucker, and B. Burrous. Identification of a 110 Kd non integrin neurite promoting peptide: homology with nucleolin. Arch. Biochem. Biophys., 290: 220 225, 1990

12. Kleinman, H.K., G.C. Sephel, K. Tashiro, B.S. Weeks, B.A. Burrows, S.H. Adler, Y. Yamada, and G.R. Martin. Laminin in neuronal development. N.Y. Acad. Sci., 580: 302 310, 1990

13. Kleinman, H.K. and B.S. Weeks. Laminin in Neuronal Development. Encyclopedia of Human Biology, Ed. R. Dulbecco, Academic Press Inc, N.Y., 4: 623 631, 1990

14. Weeks, B.S., J. DiSalvo, and H.K. Kleinman. Laminin mediated neurite outgrowth involves protein dephosphorylation. J. Neurosci. Res., 27: 418 426, 1990

15. Kleinman, H.K., and B.S. Weeks. The neural cell response to laminin: Active sites, receptors, and intracellular signals. Comments on Devel. Neurobiol., 1: 251 266, 1991

16. Weeks, B. S., M. E. Klotman, M. Kibbey, H. K. Kleinman, K. Yamada, P. E. Klotman. HIV 1 induced expression of integrin on human CD4+lymphocytes. J. Cell Biol., 114:847 853, 1991

17. Kittur, S., W. Adler, G. Martin, H. Kleinman, and B, Weeks. Neurotrophic effects of Alzheimers brain homogenate and cerebrospinal fluid on neuronal cell cultures. Alzheimer Disease and Associated Disorders, 6: 103 110, 1992

18. Kinsella, J. L., Grant, D. S., Weeks, B. S., and Kleinman, H. K. Protein kinase C regulates endothelial cell tube formation on basement membrane Matrigel. Exp. Cell. Res., 199: 56 62, 1992

19. Paralkar, V. M., Weeks, B. S., Yu, Y., Kleinman, H. K., and Reddi, A. H. Neurotrophic effects of bone morphogenic protein 2B and activin. J. Cell Biol., 119:1721 1728, 1992.

20. Burbello P., Gabriel G., Wujeck J., Kedar V. V., Weeks B. S., Klienman H. K., and Yamada Y., Basement membrane genes and transcription factors. Cellular and Molecular Aspects of Cirrhosis, 216: 135 145, 1992

21. Dhawan, S., Weeks, B. S., Klotman, M. E., and Klotman, P. E. Increased expression of a4bI and a5bl integrins on HTLV 1 Infected Lymphocytes. Virology, 197: 778 781, 1993

22. Weeks, B. S., Schnaper, W. H., *Holloway, E., and Kleinman, H. K. Human T cells synthesize the 92 kDa type IV collagenase (gelatinase B) J. Cellular. Phys., 157: 644, 1993

23. Kibbey, M. C., Jucker M., Weeks B. S., and Kleinman, H. K. bAmyloid precursor protein binds to the IKVAV site of laminin. Proc. Natl. Acad. Sci., 90: 9195, 1993

24. Weeks B. S., Klotman M. E., Holloway E., Stetler Stevenson W. G., Kleinman H. K., and P.E. Klotman. HIV 1 infection stimulates T cell invasiveness and synthesis of the 92 kDa type IV collagenase. AIDS Res. Hum. Retroviruses, 9: 513 518, 1993

25. Weeks B. S., Desai K., Lowenstien P. M., Holloway E., Klotman M. E., Klotman P. E., Green M., and Kleinman H. K. Identification of a novel cell attachment domain in the HIV I Tat protien and its 90 kDa cell surface binding protein. J. Biol. Chem., 268: 5279 5284, 1993

26. Kleinman, H. K., Weeks B. S., Schnaper H. W., Kibbey M. C., Yamamura K., and D. S. Grant. The Laminins: A family of basement membrane glycoproteins important in cell differentiation and tumor metastases. Vitamins and Hormones, 43:161 186, 1993

27. Wahl, S. M., Allen, J. B., Weeks, B. S., Wong, H. L., and Klotman P. E. TGFb enhances integrin expression and type IV collagenase secretion in human monocytes. 90:4577 4581, Proc. National. Acad. Sci. 1993

28. Weeks, B, Nomizu, M, *Okusu, A., *Weston, C., and N. Fuji. Lymphocytes and promonocytes attach to the polyphemusin peptide J22). Biochem. Biophys. Res. Commun., 202:470 475, 1994

29. Weeks, B. S., Schnaper, W. H., *Holloway, E., Klotman P. E., and Kleinman, H. K. 12 0 Teteradecanoylphorbol 13 acetate stimulates Human T lymphocyte adherence to the fibronectin RGD domain and the laminin IKVAV domain. Cell. Immunol., 153: 94 104,1994

30. Burbello, P., B.S. Weeks, Y. Yamada, and H.K. Kleinman. LZIP I and LZIP 2: two novel members of the bZIP family. Gene, 139: 241 245, 1994

31. Ferrari D. A., Gilles P. A., Klein N. W., Weeks B. S., Lammi Keefe C., Hillman R. E., Ying Y¬K., Maier D., Olsen P., Wemple D. W., Greenstein R., Muechler E. K., Miller R. K., and Mariona F. G., Rat embryo development on human sera is related to numbers of previous spontaneous abortions and nutritional factors. J. Obstet. Gynacol., 170: 228 236, 1994

32. Kittur, S., Endo, H., Hoh, J., Tourtellotte, W., Weeks, B., Markesbery, W., and Adler, W. Cytoskeletal neurofilament gene expression in brain tissue from Alzheimer's disease patients, Journal of Geriatric Psychiatry and Neurology, 7: 153 158, 1994

33. Ray, P., Bruggeman L., Weeks B., and P. E. Klotman. bFGF and its low affinity receptors in the pathogenesis of HIV associated nephropathy in transgenic mice. Kidney International, 46: 759¬772, 1994

34. Weeks, B., *Weston, C., *Okusu, A., Nomizu, M., and N. Fujii. The polypherneusin T22 peptide is recognized by the CD4 cell surface molecule. Biochem. Biophys. Res. Commun., 215: 626¬631, 1995

35. Nomizu, M., Weeks, B.S., *Weston, C.A., W. W. Kim, H. K. Kleinman and Y. Yamada. Structure Activity study of a laminin l chain active peptide segment Ile Lys Val Ala Val (IKVAV). FEBS letters, 365: 227 231, 1995

36. Dhawan, S., B. Weeks, H. W. Schnaper, K. Yamada, S. Yamada, and M. Meltzer. HIV I infection alters monocyte interaction with endothelial cell layers. J. Immunol., 154: 422 432, 1995

37. Weeks, B., Oldfield, E. and H. Kleinman. Neurotoxicity of the HIV I Tat transactivator to PC 12 cells requires the Tat amino acid 49 58 basic domain. J. Neuroscience Res., 42: 34 40, 1995

38. Chambers, B., G. Sackett, B. Weeks, H. K. Kleinman, and N. Klein. In vivo and in vitro embryotoxicity of domain specific antilaminin antibodies. Proc. Natl. Acad Sci., 90: 6818 6822, 1995

39. *Weston, C.A. and B.S. Weeks. bFGF stimulates U937 cell adhesion to fibronectin. Biochem. Biophys. Res. Commun., 228: 318 323, 1996

40. Weeks, B.S. and *J. luorno. Phosphatase inhibitors stimulate ICAM I and LFA I mediated aggregation of T lymphocytes. Biochem. Biophys. Res. Commun., 226: 82 87, 1996

41. Weeks, B, Burbello, P., *Weiner, M. and H. Kleinman. Laminin stimulates the expression of two mitochondrial proteins. Int. J. Dev. Neurosci. 14: 365 374, 1996

42. Weeks, B., and H. Friedman. Laminin reduces, the cell to cell spread of HSV I in human
keratinocyte cultures. Biochem. Biophys. Res. Commun. 203: 466 469, 1997

43. Saswata, B., Dubin, G., Basu, M., Weeks, B., and H. Friedman. Characterization of regions of herpes simplex virus type I glycoprotein I that form an FcR with glycoprotein E for binding monomeric IgG. J. Immunol. 158: 209 215, 1997

44. Weeks, B.S. and *R. Cooney. AIDS associated Kaposis sarcoma cells secrete a neurotrophic factor(s). Biochem. Biophys. Res. Commun. 233: 408 412, 1997

45. Weeks, B.S., Sundaresan, P., Nagashunmugam, T., Kang, E. and H.M. Friedman. The herpes simplex virus 1 glycoprotein E (gE) mediates IgG binding and cell to cell spread through distinct gE domains. Biochem. Biophys. Res. Commun. 235: 31 35, 1997

46. Kleinman, H.K., Weeks, B.S. Richard, B.L., and M.C. Kibbey, Laminin in neuronal development. Encyclopedia of Human Biology, Ed. R. Dulbecco, Academic Press Inc, N.Y., 5: 227 235, 1997

47. Nagashunmugam, T., Sundaresian, P., Weeks, B., Goldstein, L., and H. Friedman. Characterization of herpes simplex type 1 mutants: The glycoprotein E domains involved in IgG binding and cell to cell spread do not co map. J. Virol., 72: 5351 5359, 1998

48. Weeks, B.S., The role of leukocyte adhesion and matrix metalloproieinase secretion in AIDS pathogenesis. Int. J. Molec. Med., 1: 361 366. 1998

49. Weeks, B.S., Nomizu, M., *Ramchandran, R.S., Yamada, Y., and H.K. Kleinman. Laminin 1 and the RKRLQVQLSIRT laminin 1  1 globular domain peptide stimulate matrix metalloproteinase secretion by PC12 cells. Exp. Cell Res., 243: 375 382, 1998

50. Weeks, B.S., *Wilson, P.J., Heffernan, C.C., *Ahmad, A., and *K. Mahadeo. The role of protein kinase C in laminin-mediated neurite outgrowth. Biochem. Biophys. Res. Commun. 256: 98 – 103, 1999

51. Weeks, B.S., *Wilson, P.J., Heffernan, C.C., Gorra, V.A., White, L.E. and *A. Ahmad. Laminin stimulates protein tyrosine dephosphorylation in PC12 cells. Biochem. Biophys. Res. Commun. 262: 713-719, 1999

52. **Gavriil, E.S., *Cooney, R., and B.S. Weeks. Tat mediates apoptosis in vivo in the rat central nervous system. Biochem. Biophys. Res. Commun. 267:252-256, 2000

53. Weeks, B.S., *Ramchandran, R., ** Hopkins, J. and H.F. Friedman. HSV-1 and –2 pathogenesis is restricted by the epidermal basement membrane. Arch. Virol., 145: 385-396, 2000

54. Rialas C.M., Cadet P., Weeks B., Salzet M., and G.B. Stefano. Nociceptin, endomorphin-1 and 2 do not bind to the invertebrate immune 3 Opiate Receptor Subtype. Acta Pharmacol. Sin, 21: 516-520, 2000

55. Stefano, G.B., Weeks, B.S., and P. Cadet. GP120 Promotes HIV Survival by Distracting Immune Surveillance. Mod. Aspects of Immunobiology, 1: 63 - 68, 2000

56. Goumon, Y., B.S. Weeks, *M. Bougeava, F. Caseres, P. Cadet and G.B. Stefano. Identification of Morphine in the Adrenal Medullary Chromaffin PC12 cell line. Molec Brain Res., 81: 177-180, 2000

57. Rialas C.M., *Patterson, M., Weston, C., and B.S. Weeks. Laminin 1 and the RKRLQVQLSIRT laminin 1  1 globular domain peptide activate nitric oxide production in PC12 cells. Exp. Cell Res., 260:268-276, 2000

58. Weston, C., Prives, Rials, C., *Anova, L., and B.S. Weeks. Laminin activation of Cdc42 is required in the mechanism of laminin-mediated neurite outgrowth. Exp. Cell Res., 260: 274 - 378, 2000

59. Cadet, P., B.S. Weeks, Bilfinger, T.V., Casares, F., and G.B. Stefano. gp120 and Morphine Alter Mu Opiate Receptor Expression in Human Blood Vessel Endothelium. Int J Mol Med. 8:165-169, 2001

60. Weeks, B.S., **Ninche Alston, and G.B. Stefano Morphine reduces HSV-1 lesion sized in mice. Int J. Molec Med. 8:303-307, 2001

61. Weeks, B.S., Cadet, P., Touma, S., *Goldman, S., *Payne, M., and G. Stefano. Morphine inhibits indolactam V-induced U937 cell adhesion and gelatinase secretion. J. Cell Physiol. 189: 179-188, 2001

62. M. Makino, I. Okazaki, N. Nishi, *M Bougaeva, B. Weeks, A. Otaka, P. K. Nielsen, Y Yamada, and M. Nomizu. Identification of Cell Binding Sites in the Laminin Alpha 5 Chain G domain. Exp. Cell Res., 277: 95 - 106, 2002

63. ** Nandi A. and B.S. Weeks. A model for the mechanism of laminin-mediated neurite outgrowth. Cur. Top. in Pep. and Prot. Res., 7, 47-51, 2005

64. **Hoffman N, **Tran V, **Daniyan A, Ojugbele O, Pryor SC, **Bonventre JA, Flynn K, Weeks BS. Bifenthrin activates homotypic aggregation in human T-cell lines. Med Sci Monit. 2006 Mar;12(3):BR87-94, 2006

65. **Tran V, **Hoffman N, **Mofunanaya A, Pryor SC, Ojugbele O, McLaughlin A, Gibson L, **Bonventre JA, Flynn K, Weeks BS. Bifenthrin inhibits neurite outgrowth in differentiating PC12 cells. Med Sci Monit. 12 (2):BR57-62, 2006

66. **Nandi A., *Chandi D., **Lechesa R., Pryor SC., McLaughlin A., **Bonventre JA., Flynn K., and B. S. Weeks. Bifenthrin causes neurite retraction in the absence of cell death: A Model for Pesticide Neurodegeneration. Med Sci. Monit. 12,(5):BR169- 173, 2006

67. **Nandi A., *Chandi D., *Thurber C., *DeLuca L, Pryor SC., McLaughlin A, Gibson L, **Bonventre JA., Flynn K, and BS. Weeks. The Biological Effects of Bifenthrin on T-cells and Neurons: A Comparison of Activity. CATRINA, 1 (1) 9 - 14, 2006

68. Weeks, B., and P. Perez. PolicosanolPlus and neuroprevin enhance neurite regeneration and prevent neurite degeneration: Dietary supplements for nerve repair and prevention, and reduction of neurodegenerative disorders. JANA, 9(2) 24 - 29, 2006

69. Weeks, B and P. Perez., PolicosanolPlus® and NeuroprevinTM Ameliorate Pesticide-Mediated Inhibition of Neurite Outgrowth Neurite Degeneration. Med. Sci. Monit, Medical Science Monitor, 12(12) 379-384, 2006

70. Weeks, B and P. Perez., A novel vitamin C preparation enhances neurite formation and fibroblast adhesion and reduces xenobiotic-induced T-cell hyperactivation. Medical Science Monitor, 13(3):BR51-58, 2007

71. Weston C.A., G. Teressa, B.S. Weeks, and J. Prives. Agrin and Laminin Induce Acetylcholine Receptor Clustering by Convergent, Rho GTPase-dependent Signaling Pathways, Journal of Cell Science, 120(5):868-75, 2007

72. Weeks, B.S. and P. Perez. Absorption rates and free radical scavenging values of vitamin C-lipid metabolites in human lymphoblastic cells. Med Sci Monit 10:205-210, 2007.

73. Flynn K., M. Belopolsky, P.R. Warny, and B. S. Weeks. Atrazine decreases burrowing in freshwater mussels. Environmental Tox. and Chem., Under Review, 2007

74. **Nandi A., C. Bustos, C. Greggs, C. Ramjeawan and B. Weeks. The Mechanism of Bifenthrin Toxicity to PC12 Cells. Acta Biologica Hungarica., Under Review, 2007

*indicates undergraduate student co authors who worked directly under my supervision.
** indicates graduate student co authors who worked directly under my supervision.

Publications (Not Peer-Reviewed):

1. *Doscher, J and B. S. Weeks. The World-Wide AIDS Epidempic, ISSAC, 2: 25-27, 2003

2. Weeks, B.S. A Hero’s Journey to Simple Shelter: A Prose Poem, The Improper Hamptonian, 1: 29, 2003

*graduate student co-author

Honors and Accomplishments

I have created a unique compound, called "Relarian." This compound is incorporated into the commercial product, Mini Chill.

Professional Activities

I am the Chief Scientist at Stevenson Products, LLC - where I formulated the compound Relarian. The compound is incorporated into the Mini Chill drink. This is a relaxation drink with no caffeine, no calories, and does not contain melatonin - therefore you can actually relax, in contrast to falling asleep. Our website is www.minichill.com or http://www.minichill.com

See my research impact at Research Gate: https://www.researchgate.net/profile/Benjamin_Weeks/?ev...