Certificate in Teaching in Higher Education, University of Dundee (2003)
Ph.D., University of Nebraska (1981)
BA, Chemistry, Northwest Nazarene College (1975)
Physiological Chemistry Lecture
Physiological Chemistry Lab
Physiological Chemistry Rec
Research Seminars In Chemistry
Teaching Raison D’etre
I illuminate and you see
I clarify and you hear
I understand and you learn
I look and see you change
My professorial role at Adelphi University is to create and maintain positive Learning Environments where students, studying chemistry, can become Self-Directed Critical Thinkers. The academic environment presents many challenges and so I feel I must wear many hats in order for my students to be well on the road of becoming Self-Directed Critical Thinkers by the time they graduate from Adelphi University.
My three main roles, in these Learning Environments, are that of
• Keeper of the Pitch
All these roles are essential in maintaining Learning Environments, which promote deep meaningful learning.
Enzymology, Good Teaching Practices in Chemistry, and Cognition and the STEM Disciplines
In order to stimulate meaningful learning, an
undergraduate student must be presented with a challenging project that
has a reasonable chance for success and relevance to their interests. My
research interest focuses on the chemical and kinetic mechanisms of
nucleoside hydrolases (NH) and how these salvage enzymes from T. vaginalis
and T. Foetus stabilize the transition state. The role of the NH in
pyrimidine salvage is not as well understood as the NH of the purine
2008 Adelphi President Research Award ($5,000)
2006 Adelphi President Research Award ($4,500)
2005 Adelphi President Research Award ($5,000)
1994 African Regional Senior Research Fulbright Fellowship ($60,000)
Other Scholarly/Artistic Work
Parkin, D. W., (1991), Methods for the Determination of V and V/K Kinetic Isotope Effects, Chapter in Enzyme Mechanism from Isotope Effects, CRC Press, Boca Raton.
Parkin, D. W. (1998), Sessions 2 to 6, Chapters in Principles of Biology, Volume 1, University of London, ISBN 0718715470
Academic Journal Papers
Parkin, D. W.., Leung, H. B., and Schramm, V. L. (1984) J. Biol. Chem., 259, 9411-9417. Synthesis of Nucleotides with Specific Radiolabels in Ribose.
Parkin, D. W. and Schramm, V. L. (1984). Effects of Allosteric Activation on the Primary and Secondary Kinetic Isotope Effects For Three AMP Nucleosidases. J. Biol. Chem. 259, 9418-9425
Parkin, D. W. and Schramm, V. L. (1987) Catalytic and Allosteric Mechanism of AMP Nucleosidase from Primary and Beta Secondary, and Multiple Heavy Atom Kinetic Isotope Effects. Biochemistry 26, 913-920.
Mentch, F. D., Parkin, D. W., and Schramm, V. L. (1987), Transition-State Structure for N-Glycoside Hydrolysis of AMP by Acid and by AMP Nucleosidase in the Presence and Absence of Allosteric Activator. Biochemistry 26, 921-930.
Markham, G. D., Parkin, D. W., Mentch, F. D., and Schramm, V. L. (1987) Mechanism of S-Adenosylmethionine Synthetase by Kinetic Isotope Effects. J. Biol. Chem., 262, 5609-5615.
Parkin, D. W., Mentch, F. D., Banks, G. A., Horenstein, B. A., and Schramm, V. L. (1991), Transition State Analysis for a Vmax Mutant of AMP Nucleosidase by the Application of Heavy-Atom Kinetic Isotope Effects. Biochemistry, 30, 4586- 4594
Parkin, D. W., Horenstein, B. A., Abduhla, D. R., and Schramm, V. L. (1991) Nucleoside Hydrolase from Crithidia fasciculata. Metabolic Role. Purification. Specificity and Kinetic Mechanism. J. Biol. Chem., 266, 20658-20665.
Horenstein, B. A., Parkin, D. W., Estupinan, B., and Schramm, V. L. (1991). Transition State Analysis for Nucleoside Hydrolase. Biochemistry, 30, 10788-10795
Parkin, D. W. and Schramm, V. L. (1995) Binding Modes for Substrate and a Proposed Transition-State Analogue of Protozoan Nucleoside Hydrolase Biochemistry, 34, 13961-13966.
Mazzella, L. J., Parkin, D. W., Tyler, P. C., Furneau, R. H., and Schramm, V. L. (1996). Mechanistic Diagnoses of N-Ribohydrolases and Purine Nucleoside Phosphorylase. J. Am. Chem. Soc., 118, 2111-2112
Schramm, V. L., Horenstein, B. A., Bagdassarian, C. K., Schwartz, S. D., Berti, P. J., Rising, K. A., Scheuring, J., Kline, P. C., Parkin, D. W., and Merkler, D. J. (1996), Enzymatic Transition States and Inhibitor Design from Principles of Classical and Quantum Chemistry. Int. J. Quantum Chem., 81-89
Parkin, D. W. (1996) Purine-Specific Nucleoside N-Ribohydrolase from Trypanosoma brucei brucei: Purification, Specificity, and Kinetic Mechanism. J. Biol. Chem., 271, 21713-21719.
Parkin, D. W., Limberg, G., Tyler, P. C., Furneaux, R. H., Chen, X., and Schramm, V. L., (1997) Isozyme-Specific Transition State Inhibitors for the Trypanosomal Nucleoside Hydrolases, Biochemistry 36, 3528-3534.
Pelle, R., Schramm, V. L., and Parkin, D. W. (1997) Molecular Cloning and Expression of a Purine Specific N-Ribohydrolase from Trypanosoma brucei brucei, Sequence, Expression and Molecular Analysis. J. Biol. Chem., 273, 2118-2126.
Miles, R. W., Tyler, P. C., Evans, D., Furneaux, Parkin, D. W., Schramm, V. L., (1999) Iminoribitol Transition State Analogue Inhibitors of Protozoan Nucleoside Hydrolases, Biochemistry 38, 13147-13154.
Versées, W., Decanniere, K., Pellé, R., Depoorter, J., Parkin, D.W., & Steyaert, J. (2001) Structure and Function of a novel Purine-Specific Nucleoside Hydrolase from Trypanosoma vivax. J. Mol. Biol. 307, 1363-1379.
Tetaud, E., Giroud, C., Prescott, A. R., Parkin, D. W., Balz, D., Biteau, N., Balz, T., Fairlamb, A. H. (2001) Molecular Characterization of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidase in Trypanosoma brucei, Mol. Biochem. Parasitol. 116, 171-183
Honors and Accomplishments
African Regional Research Senior Fulbright Scholar
Phi Lambda Upsilon, University of Nebraska
National POGIL Facilitator
AP Chemistry Exam Grader