Faculty & Staff

BRIAN STOCKMAN

ASSISTANT PROFESSOR

CHEMISTRY

SCIENCE BUILDING
ROOM 34

p - 516-877-4139

f - 516-877-4485

e - BSTOCKMAN@ADELPHI.EDU

w - http://www.brianjstockman.blogsp ot.com

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Diplomas/Degrees

MBA, University of New Haven (2008)
PhD Biochemistry, University of Wisconsin-Madison (1989)
BS Chemistry & Zoology, University of Iowa (1985)

Recent Courses

Biochemistry I
Biochemistry Laboratory
Research Seminars In Chemistry
Research Seminars In Chemistry I
Research Seminars In Chemistry
Undergraduate Research In Chemistry I

Teaching Specializations/Interests

Biochemistry, Biophysics and Biomolecular Structure

Research Interests

Development of NMR-based activity assays, development of 19F NMR methods to characterize protein-ligand interactions, molecular recognition, macromolecular crowding effects on protein structure and function

Grants/Sponsored Research

Frederick Bettelheim Research Award, $1,200, Druggability of Adenosine/Guanosine Preferring Nucleoside Ribohydrolase, awarded April 2014.

Adelphi Faculty Development Grant, $3,450, Structure-activity Relationships of Prazole Inhibitors of Uridine Nucleoside Ribohydrolase, awarded February 2014.

Adelphi Faculty Development Grant, $2,500, Macromolecular Crowding Effects on the Structure of the Electron Transfer Protein Flavodoxin, awarded February 2012

Adelphi University Instructional Technology Grant, $2,068 joint with M. A. VanAlstine, Molecular Visualization and Presentation Software to Improve Chemistry and Biochemistry Learning Outcomes, awarded February 2011

Adelphi Faculty Development Grant, $4,250, Proof-of-concept NMR Studies on Uniformly 15N-labeled Uridine-specific N-ribohydrolase from Trichomonas vaginalis, awarded February 2010

Book Chapters

Stockman, B. J. (1996). Preparation of 2H, 13C and 15N Isotopically-Enriched Proteins for NMR Spectroscopic Investigations. In Sarkar, S. K. (Eds.). NMR Spectroscopy and its Application to Biomedical Research. (pp. 159-185). Amsterdam, Netherlands: Elsevier.

Stockman, B. J. & Markley, J. L. (1990). Stable-Isotope-Assisted Protein NMR Spectroscopy in Solution. In Bush, C. A. (Eds.). Advances in Biophysical Chemistry Volume 1. (pp. 1-46). Greenwich, CT: JAI Press.

Stockman, B. J. & Markley, J. L. (1989). Methods of Stable-Isotope-Assisted Protein NMR Spectroscopy in Solution. In Jardetzky, O. (Eds.). Protein Structure and Engineering. (pp. 152-192). New York, NY: Plenum.


Refereed Articles

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Stockman, B. J., Asheld, J. S., Burburan, P. J., Galesic, A., Nawlo, Z. & Sikorski, K. F. (2014), Design and characterization of a Zn2+-binding four-helix bundle protein in the biophysical chemistry laboratory. Journal of Chemical Education, 91, 451-454.

Shea, T. A., Burburan, P. J., Matubia, V. N., Ramcharan, S. S., Rosario Jr., I., Parkin, D. W. & Stockman, B. J. (2014), Identification of proton-pump inhibitor drugs that inhibit Trichomonas vaginalis uridine nucleoside ribohydrolase. Bioorganic & Medicinal Chemistry Letters, 24, 1080-1084.

Pacholec, M., Bleasdale, J. E., Chrunyk, B., Cunningham, D., Flynn, D., Garofalo, R. S., Griffith, D., Griffor, M., Loulakis, P., Pabst, B., Qiu, X., Stockman, B., Thanabal, V., Varghese, A., Ward, J., Withka, J. & Ahn, K. (2010), SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. Journal of Biological Chemistry, 285, 8340-8351.

Sahasrabudhe, P. V. & Stockman, B. J. (2009), Resonance assignments for stromelysin complexed with a beta-sulfonyl hydroxamate inhibitor. Biomolecular NMR Assignments, 3, 183-186.

Stockman, B. J., Kothe, M., Kohls, D., Weibley, L., Connolly, B. J., Sheils, A. L., Cao, Q., Cheng, A. C., Yang, L., Kamath, A. V., Ding, Y.-H. & Charlton, M. E. (2009), Identification of allosteric PIF-pocket ligands for PDK1 using NMR-based fragment screening and 1H-15N TROSY experiments. Chemical Biology & Drug Design, 73, 179-188.

Stockman, B. J. (2008), 2-Fluoro-ATP as a versatile tool for 19F NMR-based activity screening. Journal of the American Chemical Society, 130, 5870-5871.

Stockman, B. J., Lodovice, I. J., Fisher, D. A., McColl, A. S. & Xie, Z. (2007), An NMR-based functional assay for NAD synthetase. Journal of Biomolecular Screening, 12, 457-463.

Dalvit, C., Fagerness, P. E., Hadden, D. T. A., Sarver, R. W. & Stockman, B. J. (2003), Fluorine-NMR experiments for high-throughput screening: theoretical aspects, practical considerations and range of applicability. Journal of the American Chemical Society, 125, 7696-7703.

Dalvit, C., Hadden, D. T. A., Sarver, R. W., Ho, A. M. & Stockman, B. J. (2003), Multi-selective one dimensional proton NMR experiments for rapid screening and binding affinity measurements. Combinatorial Chemistry & High Throughput Screening, 6, 445-453.

Dalvit, C., Flocco, M., Knapp, S., Mostardini, M., Perego, R., Stockman, B. J., Veronesi, M. & Varasi, M. (2002), High-throughput NMR-based screening with competition binding experiments. Journal of the American Chemical Society, 124, 7702-7709.

Dalvit, C., Flocco, M., Veronesi, M. & Stockman, B. J. (2002), Fluorine-NMR competition binding experiments for high-throughput screening of large compound mixtures. Combinatorial Chemistry & High Throughput Screening, 5, 605-611.

Dalvit, C., Flocco, M., Stockman, B. J. & Veronesi, M. (2002), Competition binding experiments for rapidly ranking lead molecules for their binding affinity to human serum albumin. Combinatorial Chemistry & High Throughput Screening, 5, 645-650.


Invited Presentation/Lecture

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Stockman, B. J., Shea, T. A., Burburan, P. J., Matubia, V. N., Ramcharan, S. S., Rosario Jr., I. & Parkin, D. W. (2013, October). Identification of Trichomonas vaginalis uridine nucleoside ribohydrolase inhibitors using an 19F NMR-based activity assay. American Chemical Society Northeast Regional Meeting, New Haven, CT.

Stockman, B. J. (2013, April). Crowding & Screening: Early Results From Two Undergraduate Research Projects. Hobart and William Smith College, Geneva, NY.

Stockman, B. J. (2010, October). Fragment Screening Using NMR-based Activity Assays. Connecticut College, New London, CT.

Stockman, B. J., Lodovice, I. J., Fisher, D. A., McColl, A. S. & Xie, Z. (2007, January). An NMR-based Functional Assay for NAD Synthetase. Keystone Symposium on Frontiers of NMR in Molecular Biology X, Snowbird, UT.

Stockman, B. J. (2006, September). Adding Value to NMR-Based Fragment Screens By Using Competition Binding or Functional Assays. 232nd American Chemical Society Fall National Meeting, San Francisco, CA.

Stockman, B. J. (2004, November). Competition-Based NMR Binding Assays. Eastern Analytical Symposium, Somerset, NJ.

Stockman, B. J. (2003, March). NMR Screening: Impacting Medicinal Chemistry and Biology. PITTCON 2003, Orlando, FL.

Stockman, B. J. (2000, May). Applications of Flow NMR Spectroscopy to Monitor Binding of Small Molecules to Proteins. NMR in the Drug Discovery Pipeline, London, UK.

Stockman, B. J., Scahill, T. A., Kloosterman, D. A., Jacobsen, E. J., Skaletzky, L. L., Marshall, V. P., Waszak, G. A. & Deibel, M. R. Jr. (1998, August). Solution Structure of Collagenase Complexed with a Lactam Hydroxamate Inhibitor. XVIIIth International Conference on Magnetic Resonance in Biological Systems, Tokyo, Japan.

Stockman, B. J. (1998, May). Matrix Metalloproteinase/Ligand Complexes: Structure, Dynamics, Calorimetry and Inhibitor Design. NATO Advanced Research Workshop: Applications of NMR to the Study of the Structure & Dynamics of Supramolecular Complexes, Sitges, Spain.

Stockman, B. J., Waldon, D. J., Yuan, P., Scahill, T. A., Belonga, K. L., Jacobsen, E. J., Treiberg, J. A., Schostarez, H. J., Mitchell, M. A., Liggett, W. F., Marshall, V. P., Petzold, G. L. & Poorman, R. A. (1996, August). NMR Analysis of Stromelysin/Ligand Complexes as a Tool for Structure Based Drug Design. XVIIth International Conference on Magnetic Resonance in Biological Systems, Keystone, CO.

Stockman, B. J., Scahill, T. A., Euvrard, A., Strakalaitis, N. A., Brunner, D. P., Yem, A. W. & Deibel, M. R. Jr. (1993, August). Solution Structure of Human Interleukin-1 Receptor Antagonist Protein Determined by NMR Spectroscopy. 206th American Chemical Society National Meeting, Chicago, IL.


Conference Presentations/Papers

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Shea, T. A., Burburan, P. J., Matubia, V. N., Ramcharan, S. S., Rosario I. Jr., Parkin, D. W. & Stockman, B. J. (2014). Identification of proton-pump inhibiting drugs as inhibitors of trichomonas vaginalis uridine nucleoside ribohydrolase using an 19F NMR-based activity assay. In American Chemical Society 247th National Meeting. Dallas, TX.

Stockman, B. J. (2011). 19F NMR-based Activity Assays for Identifying Modulators of Function. In 35th Steenbock Symposium. Madison, WI.

Stockman, B. J., Hadden, D. T. A., Sahasrabudhe, P. V., Herberg, J. T., Hagadorn, J. C., Martin, J. P. Jr. & Rohrer, D. C. (2005). Identification of Ligand Fragments and their Binding Orientation Using WaterLOGSY and 1D Selective Inter-ligand QUIET-NOEs. In XXI International Conference on Magnetic Resonance in Biological Systems. Hyderabad, India.

Sahasrabudhe, P. V., Robarge, J. D., Hadden, D. T. A. & Stockman, B. J. (2002). To Affinity and Beyond: A Functional Genomics NMR Screening Compound Library. In XX International Conference on Magnetic Resonance in Biological Systems. Toronto, ON.

Angwin, D. T., Dalvit, C. & Stockman, B. J. (2001). Empirical Studies of WaterLOGSY and its Range of Applicability for NMR Screening. In 42nd Experimental NMR Conference. Orlando, FL.

Stockman, B. J., Farley, K. A., Angwin, D. T., Schering, C. A., Steinbrecher E. A., Shanmugasundaram, V., Lajiness, M. S., Maggiora, G. M., Bundy, G. L., Marshall, V. P., Yem, A. W., Vosters, A. F., Deibel, M. R. et al. (2000). Screening of Compound Libraries for Protein Binding Facilitated by Flow-Injection NMR Spectroscopy. In XIX International Conference on Magnetic Resonance in Biological Systems. Florence, Italy.

Stockman, B. J., Yuan, P., Waldon, D. J., Scahill, T. A., Sarver, R. W., DeZwaan, J., Belonga, K. L., Jacobsen, E. J., Treiberg, J. A., Schostarez, H. J., Mitchell, M. A., Marshall, V. P., Petzold, G. L. & Poorman, R. A. (1997). Structure, Dynamics and Calorimetry of Stromelysin/Ligand Complexes. In Keystone Symposium: Frontiers of NMR in Molecular Biology V. Taos, NM.

Stockman, B. J., Richardson, T. E. & Swenson, R. P. (1995). Structural Changes Caused by Site-Directed Mutagenesis of Tyrosine-98 in D. Vulgaris Flavodoxin Delineated by 1H and 15N NMR Spectroscopy: Implications for Redox Potential Modulation. In Keystone Symposium: Frontiers of NMR in Molecular Biology IV. Keystone, CO.

Stockman, B. J., Pollock, J. R., Scahill, T. A., Fairbanks, M. B. & Heinrikson, R. L. (1994). NMR Spectroscopy Indicates that the Mac-1 2 Integrin -Subunit I domain Adopts a Predominantly Folded Structure in Solution. In XVIth International Conference on Magnetic Resonance in Biological Systems. Veldhoven, Netherlands.

Stockman, B. J., Scahill, T. A., Euvrard, A., Strakalaitis, N. A., Brunner, D. P., Yem, A. W. & Deibel, M. R. Jr. (1993). Toward the Solution Structure of Interleukin-1 Receptor Antagonist Protein Determined by Heteronuclear Three-Dimensional NMR Spectroscopy. In Keystone Symposium: Frontiers of NMR in Molecular Biology III. Taos, NM.

Stockman, B. J., Scahill, T. A., Roy, M., Farley, K. A., Ulrich, E. L., Strakalaitis, N. A., Brunner, D. P., Yem, A. W. & Deibel, M. R. Jr. (1992). Secondary Structure and Topology of Interleukin-1 Receptor Antagonist Protein Determined by Heteronuclear Three-Dimensional NMR Spectroscopy. In , XVth International Conference on Magnetic Resonance in Biological Systems. Jerusalem, Israel.


Other Scholarly/Artistic Work

Listed as inventor or co-inventor on four United States patents:
6,677,160
6,764,858
7,377,894
7,470,543

Honors and Accomplishments

Damon Runyon-Walter Winchell Cancer Research Fund Fellowship, 1990-1991
NIH Training Grant in Cellular and Molecular Biology, 1987-1989

Professional Activities

Editorial Advisory Board of Chemical Biology & Drug Design, 2007-2012
Kalamazoo Section Chair, American Chemical Society, 2001-2002
Co-General Chair, ACS Central/Great Lakes Joint Regional Meeting, 2001

Community and Corporate Leadership

Waterford Education Foundation, 2007-2010
Kalamazoo Board of Education, 1995-1999