Faculty & Staff

ALAN R SCHOENFELD

ASSOCIATE PROFESSOR AND CHAIR

BIOLOGY

SCIENCE BUILDING
ROOM 102

p - 516-877-4211

f - 516-877-4209

e - SCHOENFELD@ADELPHI.EDU

w - http://home.adelphi.edu/~sc17039 /

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Diplomas/Degrees

Ph.D, Albert Einstein College of Medicine (Yeshiva University) (1999)
B.S., State University of New York at Stony Brook (1987)

Recent Courses

Cell Biology II: Advanced Topics
Continuous Matriculation
Graduate Genetics
Guided Research Vhl Cancer Research
Special Research Problems Human Anatomy And Animal Behavior
Supervised Research For Community College Students Vhl Research
Thesis Research Light-Activated Transcription
Thesis Research Vhl Cancer Research

Teaching Specializations/Interests

Genetics, cell biology, molecular biology, cancer biology

Research Interests

Cancer genetics and tumor suppressor genes: specifically, the normal cellular functions of the BRCA2 and VHL tumor suppressor genes.

For more information, please visit http://home.adelphi.edu/~sc17039/

Grants/Sponsored Research

Current support:
National Institutes of Health Academic Research Enhancement Award (AREA) grant (2011-2014) to investigate the normal cellular functions of the von Hippel-Lindau tumor suppressor gene product.

Past support:
National Institutes of Health Academic Research Enhancement Award (AREA) grant (2006-2009) to investigate the mechanisms responsible for tumors that are caused by mutations in the von Hippel-Lindau tumor suppressor gene.

Refereed Articles

see "Other Scholarly/Artistic Work" field (2012).


Invited Presentation/Lecture

A. Schoenfeld (2010, October). Cellular insights into von Hippel-Lindau tumor suppressor gene function. Nassau Community College, Garden City, NY.

A. Schoenfeld (2009, February). Cancer: the search for new and improved treatments. Saturday Science Seminar Series, Adelphi University.

A. Schoenfeld (2008, April). Cancer: Looking for Cures. Saturday Science Seminar Series, Adelphi University.

A. Schoenfeld (2007, December). Cellular insights into von Hippel-Lindau tumor suppressor gene function. Adelphi University Interdisciplinary Seminar.

A. Schoenfeld (2007, May). Cancer: Why havenít they found a cure. Nassau Science Explorations, at Nassau Community College, Garden City, NY.


Conference Presentations/Papers

Michalik, A., Abraham, S., Choi, S.-g., Petrov, V., and Schoenfeld, A (2012). Effects of atypical PKC on pVHL-mediated cellular phenotypes. In Meeting on Mechanisms and Models of Cancer. Cold Spring Harbor Laboratories, Cold Spring Harbor, NY.

Deshpande, P. and Schoenfeld A.R (2010). Effects of lower VHL levels on PC12 pheochromocytoma cells. In Metropolitan Association of College and University Biologists Annual Conference. Molloy College, Rockville Centre, NY.

Gallo, M.D. and Schoenfeld, A.R. (2009). The Effect of VHL on Apoptosis in Renal Cells. In Metropolitan Association of College and University Biologists Annual Conference. Kingsborough Community College, Brooklyn, NY.

Alexander, A., Bangiyeva, V., Popko, T., Rosenbloom, A., and Schoenfeld, A.R. (2008). VHL-mediated morphological changes are independent of HIF-alpha regulation. In Meeting on Mechanisms and Models of Cancer. Cold Spring Harbor Laboratories, Cold Spring Harbor, NY.

Kapllani, E., Hughes, M.D., Burk, R.D., and Schoenfeld, A.R. (2006). Cellular Roles for VHL gene products that are independent of HIF-alpha regulation. In Meeting on Molecular Models of Cancer. Cold Spring Harbor Laboratories, Cold Spring Harbor, NY.


Other Scholarly/Artistic Work

Bangiyeva, V., Rosenbloom, A., Alexander, A.E., Isanova, B., Popko, T., and Schoenfeld, A.R. (2009). Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes. BMC Cancer 2009, 9(1):229. http://www.biomedcentral.com/1471-2407/9/229

Tannenbaum B., Mofunanya T., Schoenfeld A.R. (2007). DNA damage repair is unaffected by mimicked heterozygous levels of BRCA2 in HT-29 cells. Int. J. Biol. Sci. 3, 402-407. http://www.biolsci.org/v03p0402.htm

Hughes, M.D., Kapllani, E., Alexander, A.E., Burk, R.D., and Schoenfeld, A.R. (2007). HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation. Cancer Cell Int. 7:13. http://www.cancerci.com/content/7/1/13

Schoenfeld, A.R., Apgar, S., Dolios, G., Wang, R., and Aaronson, S.A. (2004). BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. Mol. Cell. Biol. 24, 7444-7455.

Schoenfeld, A.R., Davidowitz, E.J., and Burk, R.D. (2001). Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau (VHL) gene products is mediated by a 64 amino acid region. Int. J. Cancer 91, 457-467.

Devarajan, P., DeLeon, M., Talasazan, F., Schoenfeld, A.R., Davidowitz, E.J., and Burk, R.D. (2001). The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways. J. Biol. Chem. 276, 40599-40605.

Davidowitz, E.J., Schoenfeld, A.R., and Burk, R.D. (2001). VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling. Mol. Cell. Biol. 21, 865-874.

Schoenfeld, A.R., Davidowitz, E.J., and Burk, R.D. (2000). Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products. Proc. Natl. Acad. Sci. USA 97, 8507-8512.

Schoenfeld, A.R., Parris T., Eisenberger A., Davidowitz E.J., De Leon M., Talasazan F., Devarajan P., and Burk, R.D. (2000). The von Hippel-Lindau tumor suppressor gene protects cells from UV-mediated apoptosis. Oncogene 19, 5851-5857.

Schoenfeld, A., Davidowitz, E.J., and Burk, R.D (1998). A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc. Natl. Acad. Sci. USA 95, 8817-8822.

Bai, S., Schoenfeld, A., Pietrangelo , A., and Burk, R.D. (1995). Basal promoter of the rat connexin 32 gene: identification and characterization of an essential element and its DNA-binding protein. Mol. Cell. Biol. 15, 1439-1445.

Professional Activities

Member, editorial board for Journal of Cancer Research. Ad hoc reviewer for the journals PLoS One, Oncogene, International Journal of Radiation Biology, Open Biology, and International Journal of Biological Sciences